Transfusion and alloimmunization in sickle cell disease. The Cooperative Study of Sickle Cell Disease

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چکیده

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Transfusion and Alloimmunization in Sickle Cell Disease

In 1,814 patients with sickle cell disease who had been transfused, the overall rate of alloimmunization to erythrocyte antigens was 18.6%. The rate of alloimmunization in this group appears to be an explicit function of the number of transfusions received because it increases exponentially with increasing numbers of transfusions. Alloimmunization usually occurred with less than 15 transfusions...

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Red blood cell transfusions have reduced morbidity and mortality for patients with sickle cell disease. Transfusions can lead to erythrocyte alloimmunization, however, with serious complications for the patient including life-threatening delayed hemolytic transfusion reactions and difficulty in finding compatible units, which can cause transfusion delays. In this review, we discuss the risk fac...

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ژورنال

عنوان ژورنال: Blood

سال: 1990

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v76.7.1431.1431